Pesticide Exposure in Children: Intervention Study Placed Children On An ORGANIC DIET (Produced Without Pesticide) And Observed Drastic And Immediate Decrease In Urinary Excretion Of Pesticide Metabolites

FULL PDF: Pesticide Exposure In Children

Pesticide Exposure in Children (Pediatrics, Nov 26, 2012):

From the American Academy of Pediatrics

Policy Statement

Pesticide Exposure in Children



This statement presents the position of the American Academy of Pediatrics on pesticides. Pesticides are a collective term for chemicals intended to kill unwanted insects, plants, molds, and rodents. Children encounter pesticides daily and have unique susceptibilities to their potential toxicity. Acute poisoning risks are clear, and understanding of chronic health implications from both acute and chronic exposure are emerging. Epidemiologic evidence demonstrates associations between early life exposure to pesticides and pediatric cancers, decreased cognitive function, and behavioral problems. Related animal toxicology studies provide supportive biological plausibility for these findings. Recognizing and reducing problematic exposures will require attention to current inadequacies in medical training, public health tracking, and regulatory action on pesticides. Ongoing research describing toxicologic vulnerabilities and exposure factors across the life span are needed to inform regulatory needs and appropriate interventions. Policies that promote integrated pest management, comprehensive pesticide labeling, and marketing practices that incorporate child health considerations will enhance safe use.


Pesticides represent a large group of products designed to kill or harm living organisms from insects to rodents to unwanted plants or animals (eg, rodents), making them inherently toxic (Table 1). Beyond acute poisoning, the influences of low-level exposures on child health are of increasing concern. This policy statement presents the position of the American Academy of Pediatrics on exposure to these products. It was developed in conjunction with a technical report that provides a thorough review of topics presented here: steps that pediatricians should take to identify pesticide poisoning, evaluate patients for pesticide-related illness, provide appropriate treatment, and prevent unnecessary exposure and poisoning.1 Recommendations for a regulatory agenda are provided as well, recognizing the role of federal agencies in ensuring the safety of children while balancing the positive attributes of pesticides. Repellents reviewed previously (eg, N,N-diethyl-meta-toluamide, commonly known as DEET; picaridin) are not discussed.2

Sources and Mechanisms of Exposure

Children encounter pesticides daily in air, food, dust, and soil and on surfaces through home and public lawn or garden application, household insecticide use, application to pets, and agricultural product residues.39For many children, diet may be the most influential source, as illustrated by an intervention study that placed children on an organic diet (produced without pesticide) and observed drastic and immediate decrease in urinary excretion of pesticide metabolites.10 In agricultural settings, pesticide spray drift is important for residences near treated crops or by take-home exposure on clothing and footwear of agricultural workers.9,11,12 Teen workers may have occupational exposures on the farm or in lawn care.1315 Heavy use of pesticides may also occur in urban pest control.16

Most serious acute poisoning occurs after unintentional ingestion, although poisoning may also follow inhalational exposure (particularly from fumigants) or significant dermal exposure.17

Acute Pesticide Toxicity

Clinical Signs and Symptoms

High-dose pesticide exposure may result in immediate, devastating, even lethal consequences. Table 2 summarizes features of clinical toxicity for the major pesticides classes. It highlights the similarities of common classes of pesticides (eg, organophosphates, carbamates, and pyrethroids) and underscores the importance of discriminating among them because treatment modalities differ. Having an index of suspicion based on familiarity with toxic mechanisms and taking an environmental history provides the opportunity for discerning a pesticide’s role in clinical decision-making.18 Pediatric care providers have a poor track record for recognition of acute pesticide poisoning.1921 This reflects their self-reported lack of medical education and self-efficacy on the topic.2226 More in-depth review of acute toxicity and management can be found in the accompanying technical report or recommended resources in Table 3.

View this table:


Common Pesticides: Signs, Symptoms, and Management Considerationsa

View this table:


Pesticide and Child Health Resources for the Pediatrician

The local or regional poison control center plays an important role as a resource for any suspected pesticide poisoning.

There is no current reliable way to determine the incidence of pesticide exposure and illness in US children. Existing data systems, such as the American Association of Poison Control Centers’ National Poison Data System or the National Institute for Occupational Safety and Health’s Sentinel Event Notification System for Occupational Risks,27,28 capture limited information about acute poisoning and trends over time.

There is also no national systematic reporting on the use of pesticides by consumers or licensed professionals. The last national survey of consumer pesticide use in homes and gardens was in 1993 (Research Triangle Institute study).29

Improved physician education, accessible and reliable biomarkers, and better diagnostic testing methods to readily identify suspected pesticide illness would significantly improve reporting and surveillance. Such tools would be equally important in improving clinical decision-making and reassuring families if pesticides can be eliminated from the differential diagnosis.

The Pesticide Label

The pesticide label contains information for understanding and preventing acute health consequences: the active ingredient; signal words identifying acute toxicity potential; US Environmental Protection Agency (EPA) registration number; directions for use, including protective equipment recommendations, storage, and disposal; and manufacturer’s contact information.30 Basic first aid advice is provided, and some labels contain a “note for physicians” with specific relevant medical information. The label does not specify the pesticide class or “other”/“inert” ingredients that may have significant toxicity and can account for up to 99% of the product.

Chronic toxicity information is not included, and labels are predominantly available in English. There is significant use of illegal pesticides (especially in immigrant communities), off-label use, and overuse, underscoring the importance of education, monitoring, and enforcement.31

Chronic Effects

Dosing experiments in animals clearly demonstrate the acute and chronic toxicity potential of multiple pesticides. Many pesticide chemicals are classified by the US EPA as carcinogens. The past decade has seen an expansion of the epidemiologic evidence base supporting adverse effects after acute and chronic pesticide exposure in children. This includes increasingly sophisticated studies addressing combined exposures and genetic susceptibility.1

Chronic toxicity end points identified in epidemiologic studies include adverse birth outcomes including preterm birth, low birth weight, and congenital anomalies, pediatric cancers, neurobehavioral and cognitive deficits, and asthma. These are reviewed in the accompanying technical report. The evidence base is most robust for associations to pediatric cancer and adverse neurodevelopment. Multiple case-control studies and evidence reviews support a role for insecticides in risk of brain tumors and acute lymphocytic leukemia. Prospective contemporary birth cohort studies in the United States link early-life exposure to organophosphate insecticides with reductions in IQ and abnormal behaviors associated with attention-deficit/hyperactivity disorder and autism. The need to better understand the health implications of ongoing pesticide use practices on child health has benefited from these observational epidemiologic data.32

Exposure Prevention Approaches

The concerning and expanding evidence base of chronic health consequences of pesticide exposure underscores the importance of efforts aimed at decreasing exposure.

Integrated pest management (IPM) is an established but undersupported approach to pest control designed to minimize and, in some cases, replace the use of pesticide chemicals while achieving acceptable control of pest populations.33 IPM programs and knowledge have been implemented in agriculture and to address weeds and pest control in residential settings and schools, commercial structures, lawn and turf, and community gardens. Reliable resources are available from the US EPA and University of California—Davis (Table 3). Other local policy approaches in use are posting warning signs of pesticide use, restricting spray zone buffers at schools, or restricting specific types of pesticide products in schools. Pediatricians can play a role in promotion of development of model programs and practices in the communities and schools of their patients.


Three overarching principles can be identified: (1) pesticide exposures are common and cause both acute and chronic effects; (2) pediatricians need to be knowledgeable in pesticide identification, counseling, and management; and (3) governmental actions to improve pesticide safety are needed. Whenever new public policy is developed or existing policy is revised, the wide range of consequences of pesticide use on children and their families should be considered. The American Academy of Pediatrics, through its chapters, committees, councils, sections, and staff, can provide information and support for public policy advocacy efforts. See for additional information or contact chapter leadership.

Recommendations to Pediatricians
  1. Acute exposures: become familiar with the clinical signs and symptoms of acute intoxication from the major types of pesticides. Be able to translate clinical knowledge about pesticide hazards into an appropriate exposure history for pesticide poisoning.

  2. Chronic exposures: become familiar with the subclinical effects of chronic exposures and routes of exposures from the major types of pesticides.

  3. Resource identification: know locally available resources for acute toxicity management and chronic low-dose exposure (see Table 3).

  4. Pesticide labeling knowledge: Understand the usefulness and limitations of pesticide chemical information on pesticide product labels.

  5. Counseling: Ask parents about pesticide use in or around the home to help determine the need for providing targeted anticipatory guidance. Recommend use of minimal-risk products, safe storage practices, and application of IPM (least toxic methods), whenever possible.

  6. Advocacy: work with schools and governmental agencies to advocate for application of least toxic pesticides by using IPM principles. Promote community right-to-know procedures when pesticide spraying occurs in public areas.

Recommendations to Government

  1. Marketing: ensure that pesticide products as marketed are not attractive to children.

  2. Labeling: include chemical ingredient identity on the label and/or the manufacturer’s Web site for all product constituents, including inert ingredients, carriers, and solvents. Include a label section specific to “Risks to children,” which informs users whether there is evidence that the active or inert ingredients have any known chronic or developmental health concerns for children. Enforce labeling practices that ensure users have adequate information on product contents, acute and chronic toxicity potential, and emergency information. Consider printing or making available labels in Spanish in addition to English.

  3. Exposure reduction: set goal to reduce exposure overall. Promote application methods and practices that minimize children’s exposure, such as using bait stations and gels, advising against overuse of pediculicides. Promote education regarding proper storage of product.

  4. Reporting: make pesticide-related suspected poisoning universally reportable and support a systematic central repository of such incidents to optimize national surveillance.

  5. Exportation: aid in identification of least toxic alternatives to pesticide use internationally, and unless safer alternatives are not available or are impossible to implement, ban export of products that are banned or restricted for toxicity concerns in the United States.

  6. Safety: continue to evaluate pesticide safety. Enforce community right-to-know procedures when pesticide spraying occurs in public areas. Develop, strengthen, and enforce standards of removal of concerning products for home or child product use. Require development of a human biomarker, such as a urinary or blood measure, that can be used to identify exposure and/or early health implications with new pesticide chemical registration or reregistration of existing products. Developmental toxicity, including endocrine disruption, should be a priority when evaluating new chemicals for licensing or reregistration of existing products.

  7. Advance less toxic pesticide alternatives: increase economic incentives for growers who adopt IPM, including less toxic pesticides. Support research to expand and improve IPM in agriculture and nonagricultural pest control.

  8. Research: support toxicologic and epidemiologic research to better identify and understand health risks associated with children’s exposure to pesticides. Consider supporting another national study of pesticide use in the home and garden setting of US households as a targeted initiative or through cooperation with existing research opportunities (eg, National Children’s Study, NHANES).

  9. Health provider education and support: support educational efforts to increase the capacity of pediatric health care providers to diagnose and manage acute pesticide poisoning and reduce pesticide exposure and potential chronic pesticide effects in children. Provide support to systems such as Poison Control Centers to provide timely, expert advice on exposures. Require the development of diagnostic tests to assist providers with diagnosing (and ruling out) pesticide poisoning.

Lead Authors

James R. Roberts, MD, MPH

Catherine J. Karr, MD, PhD

Council on Environmental Health Executive Committee, 2012–2013

Jerome A. Paulson, MD, Chairperson

Alice C. Brock-Utne, MD

Heather L. Brumberg, MD, MPH

Carla C. Campbell, MD

Bruce P. Lanphear, MD, MPH

Kevin C. Osterhoudt, MD, MSCE

Megan T. Sandel, MD

Leonardo Trasande, MD, MPP

Robert O. Wright, MD, MPH

Former Executive Committee Members

Helen J. Binns, MD, MPH

James R. Roberts, MD, MPH

Catherine J. Karr, MD, PhD

Joel A. Forman, MD

James M. Seltzer, MD


Mary Mortensen, MD – Centers for Disease Control and Prevention/National Center for Environmental Health

Walter J. Rogan, MD – National Institute of Environmental Health Sciences

Sharon Savage, MD – National Cancer Institute


Paul Spire

  • This document is copyrighted and is property of the American Academy of Pediatrics and its Board of Directors. All authors have filed conflict of interest statements with the American Academy of Pediatrics. Any conflicts have been resolved through a process approved by the Board of Directors. The American Academy of Pediatrics has neither solicited nor accepted any commercial involvement in the development of the content of this publication.

  • All policy statements from the American Academy of Pediatrics automatically expire 5 years after publication unless reaffirmed, revised, or retired at or before that time.

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